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KMID : 1059520110550040626
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Journal of the Korean Chemical Society
2011 Volume.55 No. 4 p.626 ~ p.632
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Analysis of Phoxim Residue in Animal Food Production (Cattle and Pig) by LC/ESI-MS/MS
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Park Mi-Sun
Myung Seung-Woon
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Abstract
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Phoxim, which is one of veterinary drugs, is a well-known antiparasitic agent in wide use. In this paper, phoxim
was extracted from cattle and pig tissue using solid-phase extraction (SPE) employing a silica cartridge with acetonitrile. Liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) for the analysis of phoxim from animal tissue was presented. Phoxim was detected on a C18 column (2.1×100 mm, 3.5 μm) using a mobile phase of 0.1% formic acid in water and acetonitrile. A linear correlation observed in the calibration curves for cattle (0.0048~2.0 mg/kg) and pig (0.0055~2.0 mg/kg) showed above r2=0.995. Accuracy measured at concentrations ranging from 0.0048 to 0.2 mg/kg was the range of 68.2~106.9%. Limit of detection (LOD) and limit of quantitation (LOQ) were the range of 0.0014~0.0017 mg/kg and 0.0048~0.0055 mg/kg, respectively. The precision (RSD%) was below 11.2%.
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KEYWORD
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Phoxim, Veterinary drugs, Animal food products, LC/ESI-MS/MS
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